Managing Tight Binding Receptors for New Separations Technologies

This program is fully staffed and all proposed investigations are proceeding as outlined in the Task Schedule of our original proposal. The program aims remain unchanged and excellent progress is reported below. We anticipate no substantial unexpended funds from the first year’s budget at the end of the first year of support. Any such remaining funds will certainly be less than 10% of the budget; less than 5% is expected. Three projects make up this program and each focuses on a single aspect of the major problem of overcoming the inherent slow reaction rates of tight-binding ligands. In a logical order, Project 1 addresses the rates of formation of metal complexes using tight-binding ligands; Project 2 addresses the rate of release of metal ions from complexes with tight-binding ligands; and Project 3 provides the possibility of a new technology that should be unimpeded by the inherent dilatory rates.